Biased perspectives on formyl peptide receptors
نویسندگان
چکیده
منابع مشابه
Activation of professional phagocytes with emphasis on formyl peptide receptors
Phagocytic cells such as neutrophil granulocytes and monocytes are an essential part of our innate immune system and play an important role in the battle against pathogens. G-protein coupled receptors (GPCRs) and more specifically chemoattractant receptors are a vital part in guiding phagocytes towards the site of infection. Chemoattractant receptors are also involved in an effective activation...
متن کاملExpression of Formyl-peptide Receptors in Human Lung Carcinoma.
BACKGROUND/AIM Formyl-peptide receptors (FPRs) are expressed in several tissues and cell types. The identification of markers involved in cell growth may further allow for molecular profiling of lung cancer. We investigated the possible role of FPRs as molecular markers in several types of lung carcinomas which is the main cause of cancer death worldwide. MATERIALS AND METHODS Tumor tissue sa...
متن کاملAcquisition of formyl peptide receptors during normal human myeloid differentiation.
By using a newly developed immune rosetting technique to isolate highly purified populations of myeloid precursor cells from normal human bone marrow and then inducing their differentiation with granulocyte and macrophage colony-stimulating factors (G/M-CSFs) in vitro, we studied the surface expression of chemotactic peptide receptors as the cells matured from the stage of the myeloblast to tha...
متن کاملHuman platelets exhibit chemotaxis using functional N-formyl peptide receptors.
OBJECTIVE Activated platelets participate in inflammatory and microbicidal processes by upregulation of surface selectins, shedding of CD40 ligand, and release of platelet microbicidal proteins and microparticles. Given their myeloid lineage, we hypothesized that platelets express functional N-formyl peptide receptors and respond to the bacterially derived chemotactic peptide N-formyl peptide w...
متن کاملFunctional characterization of three mouse formyl peptide receptors.
The evolutionary relationship and functional correlation between human formyl peptide receptors (FPRs) and their mouse counterparts remain incompletely understood. We examined three members of the mouse formyl peptide receptor subfamily (mFprs) and found that they differ in agonist preference and cellular distributions. When stably expressed in transfected rat basophilic leukemia (RBL-2H3) cell...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2019
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2018.11.015